Adrian Gonzalez lifted the Padres into a 2-2 tie in the eighth with a solo homer, but San Diego eventually lost its third straight when Trevor Hoffman (1-6) allowed a two-out rally in the 10th.

Emmanuel Burriss singled off Hoffman and Velez came through with a pinch-hit double to deep right.

San Diego produced three straight one-out singles in the bottom of the 10th to load the bases, but Brian Wilson got Kevin Kouzmanoff to ground into a game-ending double play.

Wilson recorded his 29th save to preserve the win for Sergio Romo (1-1), who had worked the ninth.