Nolasco (10-4) finished with seven strikeouts and ran his personal victory streak to a career-high five straight.

Kevin Gregg picked up his 16h save with a perfect ninth.

Jorge Cantu drove in two runs with a home run and Alfredo Amezaga had three hits for the Marlins, who won their second straight game.

Padres starter Greg Maddux (3-7) was the hard-luck loser, allowing just two runs -- one earned -- on four hits in six innings.

Bryan Corey let in one run in two innings of relief of Maddux.

Chase Headley accounted for San Diego's lone run with a fifth-inning homer.