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Nadal, Murray reach U.S. Open semis
Romero finished at 18-under 199 at the En-Joie Golf Club.
Gary Koch (65) and Fulton Allem (69) shared second place at 16-under 201, and Joey Sindelar (71) placed fourth, another two strokes back.
Bruce Vaughan (69) and Joe Ozaki (70) tied for fifth at 13-under-par 203.
"It was a very important win for me. I worked hard for this victory," said Romero, who led by one shot starting the final round. "I played fantastic this week, especially today."
Romero's other win on the tour was at the JELD-WEN Tradition in 2006.
