Phelps won in a time of 50.89 seconds to beat world record-holder Ian Crocker (51.62), and Gil Stovall (52.08). Phelps's four other titles at these trials were in the 200 and 400 individual medleys, the 200 free and 200 butterfly.

Margaret Hoelzer set a world record in winning the 200-meter backstroke. She finished in a time of two minutes, 6.09 seconds, besting the previous world mark of Zimbabwe's Kirsty Coventry (2:06.39).

Elizabeth Beisel, who was named to the Olympic team due to a second-place finish in the 400-meter individual medley, was second at 2:06.92, while Hayley McGregory, who set the early pace was third at 2:07.69.

Hoelzer was the fifth-place finisher in the 200 backstroke at the 2004 Olympics in Athens.