The Blue Jays won for the third time in four games on the heels of a seven-game losing streak.
Litsch (8-4) struck out six and walked only one. He was staked to a 5-0 lead before giving up the Reds' lone run in the fourth.
Scott Rolen put Toronto in front in the second with a two-run homer, one of just six hits the Blue Jays managed in the game. Lyle Overbay contributed a two-run single during Toronto's three-run third.
In his worst start of the season, Edinson Volquez (10-3) took the loss. He allowed seven runs on seven hits in 4 1/3.
The Reds have lost three out of four.