The game featured the 2,416th hit in the career of Derek Jeter, who moved past Mickey Mantle into third place on the Yankees' all-time list. Jeter's milestone hit, a third-inning single, drove in Jose Molina with the first run of the contest.
Wilson Betemit added a solo homer in helping the Yankees halt a three-game losing streak.
Mike Mussina improved to 9-4 by allowing a run on five hits in six innings. He struck out six.
The loss went to Jesse Litsch (7-2), who gave up four runs on 10 hits in 5 1/3 innings. Toronto has dropped four out of five.