One of Votto's two hits was a three-run double in the top of the fourth and the other was a two-run homer in the sixth.
Cincinnati built a 5-2 lead through six innings.
Ken Griffey Jr. also had two hits, one a three-run homer in the seventh, the 596th homer in his career.
Winner Edinson Volquez (2-0) gave up an earned run and four hits in five innings with four walks and seven strikeouts.
Lilly (0-3) surrendered five earned runs and six hits in six innings with three walks and six strikeouts.
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