With the contest tied 5-5, two on and no outs, the veteran catcher planted an offering from Detroit reliever and losing pitcher Jason Grilli (0-1) deep into the right-field bleachers.
Pierzynski hit a two-run double in the top of the third and finished with three hits and five RBI.
Carlos Quentin had two hits, one a two-run homer in the second, and Jermaine Dye had three hits and one RBI for the White Sox, who have won two in a row while keeping the Tigers winless in their first four games.
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