Former top-ranked Lindsay Davenport was knocked out of the $3.77 million tennis tournament in Miami.
Henin, the reigning French and U.S. Open champ, beat Russian Elena Vesnina 6-2, 6-2. Henin was last year's Miami runner-up to Serena, who will oppose the Belgian star here, again, in this year's quarterfinals.
Serena beat Estonian Kaia Kanepi 6-3, 6-3 to set up the showdown with Henin. Serena is seeking her fifth title here in seven years, having won from 2002-04 and again last year.
Venus beat 17-year-old Dane Caroline Wozniacki 6-3, 6-3. The American won this tournament in 1998, 1999 and 2001.
Davenport lost to Russian Dinara Safina 6-3, 6-4.