WVU took full advantage of Duke's poor second-half shooting and won the rebounding battle by a whopping 47-27 margin in the West Region contest played at Verizon Center in Washington.
Duke, a No. 2 seed, led 34-29 at the break but an 18-3 run left seventh-seeded WVU with a 47-40 lead with 11:50 remaining.
Duke could not rally because of its cold shooting.
Long-range sharpshooter Alex Ruoff scored 17 points with six rebounds and reserve Joe Mazzulla added 13 points, 11 rebounds and eight assists for the Mountaineers (26-10), who advanced to the third round Thursday in Phoenix.
Duke got a team-high 18 points from Gerald Henderson.
Jon Scheyer scored 15 and Greg Paulus 13 with three rebounds and two assists for the Blue Devils (28-6), who failed to survive the tournament's first weekend for the second straight season.
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