Over his 26-year career, the Hickory, N.C., native has compiled 16 poles, 32 victories, 163 top fives and 260 Top-10 finishes and Sunday's race will be his 668th start.
His career earnings total more than $48 million.
"It feels very good about this being my time to walk away from the sport (as a driver)," the three-time Daytona 500 (1993, 1995, 2000) winner said recently. "It's going to be somewhat emotional because it's going to be close to my home and I am going to be able to have a lot of family and friends around."
Jarrett, 51, is following his father, Ned, into the announcer's booth when he joins the ESPN/ABC broadcast team later this year.
He plans to drive in an All-Star race in Concord, N.C., in May.