The Spartans (23-6, 11-5 Big Ten) took charge immediately and raced to a 49-16 advantage with 5:14 to go in the first half.

Drew Neitzel and Goran Suton each scored 17 points and Kalin Lucas added 14 for Michigan State.

Eric Gordon led the Hoosiers with 22 points. D.J. White scored 14 points and collected 12 rebounds.

Indiana (24-5, 13-3) lost for the first time in three games under interim coach Dan Dakich, who took charge following Kelvin Sampson's resignation.