William Thomas was born at 10:21 a.m. EST and Tyler Joseph came along about a half hour later at an undisclosed Maryland hospital. The boys are the first children for Frese and husband, Mark Thomas.
The school said on its Web site that Frese, 37, and the babies are healthy and doing well.
The Washington Post reported Sunday night that the players were told about the delivery during a pre-game shoot-around.
First-year assistant coach Daron Park has been coaching the Lady Terps on the road. Frese had been in the national limelight because she coached while pregnant at home games at Maryland's Comcast Center. She was told by her doctor not to travel.
The school said her plans to return to the sideline will be announced at a later date.