Blake defeated Igor Kunitsyn 6-2, 6-4 to lead three Americans into the semifinals.
Blake is coming off a singles victory in Davis Cup action last week. He previously reached the quarterfinals of the Australian Open before falling to Roger Federer.
In the semifinals, Blake will meet Robby Ginepri, a 6-1, 4-6, 6-4 winner over Mardy Fish.
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