The Giants wrecked the Patriots' perfect season and won the championship for the third time in franchise history. Their other titles were in 1987 and 1991.
New England had won 18 straight games this season coming into the Super Bowl. The Patriots' defeat leaves the 1972 Miami Dolphins (17-0) as the NFL's only unbeaten, untied team.
The Giants, 12-point underdogs, frustrated Patriots quarterback Tom Brady until he led his team on a long touchdown drive late in the fourth quarter. But Manning came right back, taking his team on a 12-play, 83-yard drive capped by a 13-yard scoring pass to Burress.
Manning was named MVP, following in the footsteps of his brother Peyton, who was named MVP last year when he led the Indianapolis Colts to the Super Bowl championship.
The young quarterback completed 19 of 34 passes, two for touchdowns. The other touchdown was a 5-yard pass to wide receiver David Tyree.