Patrick Beverley added 19 for the Razorbacks (15-5, 4-2 SEC), who put together a 14-0 run in the first half en route to a 15-point lead at the break.
Mississippi State had been unbeaten in conference play, a feat that allowed it to move into the national rankings this week.
The Bulldogs (14-6, 5-1) were led by Jamont Gordon with 24 points.
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