The 22nd-ranked Rebels bounced back from Southeastern Conference road losses at Auburn and Mississippi State, while the Commodores have lost all four of their league road games.
Vanderbilt (17-4, 2-4) was led by 14 points from Shan Foster. The Commodores were coming off their most one-sided defeat of the season, an 86-64 setback to Florida last weekend.
Mississippi owned a three-point halftime advantage and then went on a 15-5 run to open the second period. Vanderbilt closed its deficit to four points with 11:27 remaining only to have the Rebels quickly boost the advantage back to double digits.
Mississippi is 10-1 at home this season and is 26-1 in Oxford since Coach Andy Kennedy took over the team last season.