The victory left the Tigers (17-0, 4-0 Conference-USA) as one of only two unbeaten teams in Division I. No. 3 Kansas remained unbeaten Saturday with a 76-70 win over Missouri, but the top-ranked North Carolina Tarheels dropped their first contest of the season in an 82-80 loss at home to Maryland.
R.L. Horton and Jeremy Wise had nine points apiece for Southern Miss (9-9, 1-3). Andre Stephens finished with seven points and 10 boards.
Southern Miss kept it close for the first 12 minutes of the game, pulling to within 24-20, but Memphis took off on a 20-3 run the rest of the half and never looked back.