The Lakers shot an overwhelming 67 percent from the field in hammering the road weary 76ers. This was the fifth game of a six-game road trip for Philadelphia, which wilted in the second quarter and faded away in the second half.
Philadelphia has won just once in its last nine road games against the Lakers.
The 76ers were paced by Lou Williams with 17 points.
The Lakers had an eight-point lead after one period, and then scored the first nine points of the second. Philadelphia managed only 14 points in the second quarter and trailed at the half by 24.