Favre completed nine of 11 passes for 99 yards and two scores before being replaced by Nall in the second quarter. Nall was seven-of-15 passing for 88 yards and a touchdown for NFC North champion Green Bay (13-3).
Jon Kitna threw for 246 yard, a touchdown and two interceptions on 22-of-48 passing for the Lions (7-9), who ended the season with their best record since 2000.
Shaun McDonald ended with five receptions for 69 yards with a touchdown in the loss.
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