An ESPN report Friday said Pittsburgh Coach Jamie Dixon felt "99 percent sure" Cook suffered a season-ending injury thus ending his Pitt career because it would require surgery.
The 6-foot, 4-inch senior from Philadelphia was injured early in overtime when the knee buckled while he was taking a shot.
He screamed in pain and needed help both leaving the court and to get to the locker room.
The report added he returned to Pittsburgh with a few members of the team and coaching staff Friday instead of going home to Philadelphia for the Christmas break.
Cook was averaging 10.4 points and 2.8 rebounds in 11 games this season.