An interception by Matterral Richardson gave Arkansas its stunning victory. Richardson picked off a Matt Flynn two-point conversion attempt after Flynn had tossed a nine-yard touchdown pass to Brandon LaFell.
The loss, LSU's second this season, likely ends any hopes of a national championship for the Tigers (10-2). It was the second time in 2007 they lost while holding the No. 1 ranking.
Week after week, highly ranked teams have been knocked off, frequently by unranked opponents.
McFadden gained 205 yards on 32 carries. Hillis scored three times and Felix Jones twice.
Flynn connected on 23 of 49 passes for 210 yards and three touchdowns. Jacob Hester scored twice and gained 128 yards on 28 carries and Colt David booted two field goals for the Tigers.