Daniel's first pass was an interception. But the Tigers (8-1, 4-1 Big 12) won their third straight after their lone loss of the season, 41-31, at 5th-ranked Oklahoma.
Chase Coffman caught three of Daniel's scoring passes, as Missouri scored 48 unanswered points. Jeremy Maclin had 108 yards on six receptions for the Tigers.
Cody Hawkins completed 12-of-25 passes for 100 yards and one interception for Colorado (5-5, 3-3), which has dropped three of its last four games. Byron Ellis scored the Buffaloes' only touchdown, a 2-yard run two minutes into the first quarter.
Missouri out-scored Colorado 24-0 in the second quarter.