Brandon Cox completed 9-of-11 passes for 167 yards and a touchdown for the Tigers (7-3) and his backup, Blake Field, passed for 92 yards and a touchdown.
Ben Tate and Carl Stewart added rushing touchdowns and Walter McFadden scored on a 93-yard interception return for Auburn.
Justin Kraemer kicked a first-quarter field goal for Tennessee Tech's only score. Lee Sweeney completed 19-of-26 passes for 168 yards and an interception for the Golden Eagles (4-6), who have lost five games in a row.
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