Anthony and Iverson are beginning their first full campaign together after helping Denver reach the playoffs last season. They highlighted a racehorse game that featured 182 field goal attempts, 45 of them from three-point range.
Anthony scored 32 points and Iverson had 14 assists, just two off his career best, to go with his 25 points. Linas Kleiza made five three-point shots for Denver and scored 18 points.
The Nuggets pulled away in the fourth quarter after taking only a five-point lead into the final period.
Damien Wilkins scored 21 for Seattle and Kevin Durant had 18 in his professional debut. Durant was the second player chosen in this year's draft and his status had been questionable because of an ankle injury he suffered during the exhibition season.