Chase Daniel completed 14-of-19 passes for 210 yards and a touchdown for Missouri (6-1, 2-1 Big 12), which suffered its first loss last week to fourth-ranked Oklahoma.
Derrick Washington rushed for 66 yards and Jeremy Maclin caught two passes for 64 yards and a TD.
Graham Harrell completed 44-of-69 passes for 397 yards and a touchdown but was intercepted four times for Texas Tech (6-2, 2-2), which had a three-game winning streak snapped.
Danny Amendola caught 11 passes for 94 yards and Edward Britton caught a 68-yard touchdown pass.
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