Manning completed 27 of 39 passes for his second 300-yard game this season.

Plaxico Burress caught six Manning tosses for 97 yards with one TD as New York (4-2) won its fourth straight after starting the season 0-2. Reuben Droughns ran for 90 yards and a score and Brandon Jacobs rushed for 86 yards for the Giants, who pulled within a game of NFC East-leading Dallas.

Amani Toomer's touchdown catch tied him with Kyle Rote for the most in franchise history at 48, while his seventh and final catch gave him sole possession of the franchise's all-time lead in that category with 587. Tiki Barber held the previous record with 586. Toomer ended with 89 yards receiving.

Jerious Norwood ran for 87 yards, including a 67-yard TD run, for the Falcons (1-5), who have dropped two in a row since picking up their lone win of the season. Joey Harrington started at quarterback and finished 18-of-39 for 209 yards with no touchdowns and one interception.