The top-seeded Serbian needed just 75 minutes to earn his fifth title this season in his first outing since finishing as the runner-up to Roger Federer at the U.S. Open in September.
"I prepared really well for this tournament physically and mentally, and this is another reason to celebrate," Djokovic said. "It's great to start the indoor season with a win, and it's a good thing before Madrid, which is a major tournament, and upcoming tournaments after that."
The 20-year-old Djokovic avenged a loss to Wawrinka in the second round of this tournament last season, to earn a winner's check of $188,000 for his ATP-best 65th match win in 2007.
Wawrinka fell to 1-3 in his career in ATP title matches.
Swim Week Miami Beach 2014 [PHOTOS]