His scoring pass went to tight end Heath Miller late in the first half to give Pittsburgh a 7-0 halftime lead.
Najeh Davenport scored on a pair of short runs in the second half, and Willie Parker carried 28 times for 102 yards as the Steelers bounced back after their only loss this season at Arizona last Sunday.
Seattle quarterback Matt Hasselbeck completed just 13 of 27 passes for 116 yards with one interception.
The teams last met in the Super Bowl in 2005.
Exploding whale video goes viral on Internet
N.J. man wakes up from 10-hour sleep with knife in back