Wade held a similar post with Philadelphia from 1997-2005. He served as Houston's public relations director in the 1980s before taking a PR job with the Pittsburgh Pirates.
On their Web site, the Astros noted Wade beat out 10 other perspective candidates, including three former GMs -- Bob Watson, Jim Beattie and Dan Evans.
"He's done a terrific job in player development," McLane told the Houston Chronicle. "He's put together very, very competitive teams. He had some exciting young players. You look at the players on the Philly team. The first baseman (slugger Ryan Howard) is one of the most successful power hitters in a long, long time."
Wade was the only candidate brought in for a second interview.
He succeeds Tim Purpura, who was fired on Aug. 27 along with manager Phil Garner.