Officials of the Indianapolis Motor Speedway and Formula One Management on Thursday said they failed to reach an agreement to extend their contract for the race.
Indianapolis Motor Speedway Chief Executive Officer Tony George said "the door (was left) open for a potential future date" and he hoped that the race would return to Indianapolis.
The U.S. Grand Prix has been run for the last eight years at Indianapolis, with Michael Schumacher winning five times. There was no U.S. Grand Prix from 1992-99 and previously the race was run in Phoenix, Dallas and Watkins Glen, N.Y., among other locations.
Lewis Hamilton, a Formula One rookie driver, won the 2007 U.S. Grand Prix on June 17.