Financial aspects of the deals weren't released but the Sabres said Ruff agreed to a three-year contract with a one-year option and Regier's deal was for two years.
"Both guys represent the franchise in every way and we're very excited about what the future brings," Sabres Managing Partner Larry Quinn said. "We consider them major assets to the organization."
Ruff just completed his ninth season as the Buffalo coach and owns the franchise record for victories. The team is 358-289-91 under Ruff. Last season the Sabres were 53-22-7 and won the President's Trophy as the NHL team with the best record.
Regier has been with Buffalo since the 1997-98 season and is credited with building the team that made the NHL Eastern Conference finals each of the last two seasons.