Aubrey Huff hit a sacrifice fly for the Orioles' other run. Payton had two hits, and Melvin Mora had a run and two hits, while Nick Markakis had three hits for the Orioles, who try for a three-game series sweep Sunday.
Nook Logan and Tony Batista both drove in one run, and Dmitri Young had two of the six hits for the Nationals, who have split their last four overall.
The loser was Winston Abreu (0-1).
Starter Mike Bacsik gave up five hits in six scoreless innings with one walk and one strikeout.