The No.60 Roush Fenway Racing Ford crossed the finish line 4.673 seconds ahead of David Reutimann.
The victory was Edwards' second in a row and 11th of his Busch career.
"I'm very fortunate to drive for Roush Racing," he said.
Edwards again built a big lead after a debris caution flag on lap 180 set everyone up for a final sprint to the checkered flag.
The only thing that could stop him from cruising to back-to-back victories was a caution flag or a mechanical problem.
"We didn't have anything for Carl," said Jason Leffler.