Mario Boggan added 17 points and nine rebounds for the Cowboys (18-3, 4-2 Big 12), who have won three of their last four games.
JamesOn Curry scored 14 points for Oklahoma State, which started the second half with a 12-0 run.
Mike Taylor scored 13 points to lead the Cyclones (11-9, 2-4), who have lost four in a row. Dodie Dunson added 11 points for Iowa State.
2014: The Year in Music [PHOTOS]