Dikembe Mutombo blocked five shots, moving him past Kareem Abdul-Jabbar into second place all-time with 3,189.
Mutombo also claimed 19 rebounds as the Rockets beat the Lakers for the first time in five tries this season.
Houston finished off the third period with a 10-1 run that gave them a 72-58 lead.
Lakers Coach Phil Jackson picked up two technical fouls with 15 seconds left in the third period and was ejected from the game.
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