The Razorbacks asserted themselves as a force in their Southeastern Conference opener, improving to 12-3 for the season and winning their fourth straight.
Alabama had a six-game winning streak snapped with Alonzo Gee scoring 14 points and Mykal Riley adding 11. The Crimson Tide slipped to 13-2.
Arkansas scored the game's first 14 points and did not let up, taking a 44-20 halftime lead. Alabama came no closer than 16 points during the second half and Arkansas led by as many as 36.