The Panthers opened up a 30-10 lead with just over nine minutes left in the first half and the contest was never in doubt. They coasted in the final 20 minutes after a 42-28 halftime lead.
Robert Mitchell scored 13 points and Stephen Wood scored 12 for Duquesne. Scott Grote, Aaron Jackson and Gary Tucker all scored seven points for the Dukes (2-5), who have lost five in a row after winning their first two games.
Pittsburgh won the battle of the boards, 37-27.
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