Tomlinson had 20 carries, and also picked up 74 yards on three catches, as the Chargers (8-2) came back from a 21-point halftime deficit for a second straight week. San Diego scored 42 second-half points last week to beat Cincinnati, 49-41.
Tomlinson reach 100 touchdowns faster than any other NFL player -- reaching the milestone in 89 career games, to 93 games for Jim Brown and Emmitt Smith.
Philip Rivers was 19-of-26 passing for 222 yards and two touchdowns, with two interceptions for San Diego. Vincent Jackson had three catches for 39 yards and a score in the Chargers' fourth straight victory.
Mike Bell had 20 carries for 91 yards and two touchdowns, and Jake Plummer was 13-of-28 passing for 183 yards and one interception for the Broncos (7-3), who had a two-game winning streak snapped.
Javon Walker caught four passes for 66 yards and Damien Nash had 49 yards rushing on 10 carries for the Broncos.