Jake Delhomme completed 22-of-34 passes for 240 yards with two touchdowns and one interception for the Panthers (5-4).
Julius Peppers had three sacks to lead a Panthers defense that forced four turnovers and held the Buccaneers to just 69 yards rushing.
Bruce Gradkowski was 17-of-32 for 173 yards with a touchdown and two interceptions for Tampa Bay (2-7), which has lost three straight and scored only 27 points in those games.
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