Darius Walker rushed for 160 yards and a touchdown on 15 carries, and Samardzija caught six passes for 106 yards and the score for the Fighting Irish (9-1), who have won seven straight games after their only loss of the season.
Terrail Lambert returned a blocked field goal attempt 76 yards for a touchdown in the second quarter, and Marcus Freeman scored a third-quarter touchdown on a 23-yard pass from Quinn.
Shaun Carney was 14-of-17 for 210 yards and two touchdowns for the Falcons (4-5), who have only managed one win against Notre Dame in 12 games dating back to 1985.
Carney threw touchdown passes to Beau Suder and Jacobe Kendrick.
Notable deaths of 2014 [PHOTOS]