The Saints had to score 14 straight points to take a 17-14 lead before the half.
Brees was 24-for-32 for 314 yards.
Marques Colston and Devery Henderson caught scoring passes in the first quarter and Henderson added a scoring catch in the third when Deuce McAllister also scored on a short run for the Saints, who had beaten Tampa Bay, 24-21, in Week 5 when rookie Reggie Bush returned a punt 65 yards with under five minutes remaining for a game-winning touchdown.
Bruce Gradkowski was 18-for-31 for 185 yards and two touchdowns; Joey Galloway caught both scoring passes on four receptions for 97 yards for the Buccaneers (2-6), who have lost two games in a row since Matt Bryant's game-winning 62-yard field goal beat Philadelphia on Oct. 15.
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