Tucker's goal came at 9:20 of the second period, when the Maple Leafs scored three times to snap a 1-1 tie.
Mats Sundin had two goals and one assist, Jeff O'Neill scored once, Alexei Ponikarovsky had two assists, and Andrew Raycroft allowed one goal on 30 shots for Toronto, which handed the Sabres their first loss in regulation this season.
On the power play, Toronto went 1-for-7, and Buffalo did not score on any of its six chances.
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