The undefeated Saints scored early in their first regular season game in the rebuilt domed stadium since December 26, 2004, when Curtis Deloach recovered a blocked punt for a touchdown in the first two minutes. New Orleans took a 14-3 lead in the first quarter when Devery Henderson ran 11-yards for a touchdown on a double-reverse.
Atlanta quarterback Michael Vick completed 12-of-31 passes for 137 yards as the Falcons (2-1) managed just a field goal.
The Superdome was heavily damaged during Hurricane Katrina last year and underwent a $185 million renovation. The Saints played all their games outside New Orleans in their 3-13 2005 season.