Lowery was bogey-free over 18 holes, while Scott's round featured seven birdies and two bogeys.
Bob Estes and Brett Wetterich head into the second round tied for third place at 4-under 66.
Bubba Dickerson -- who was tied for the lead with Scott and Lowery late in his round -- bogeyed two of his final four holes and finished at 3-under 67, tied with nine other players, including Dean Wilson, Tom Herron and Bo Van Pelt.
Couple mistakenly served bag of cash at McDonald's drive-thru
Jordana Brewster on Paul Walker: 'He was an enormous presence in my life'