Ramirez, a highly touted shortstop who came to south Florida in the deal that sent pitcher Josh Beckett and Mike Lowell to Boston, had only three career runs batted in before his 3-for-6 performance on Tuesday. He also scored three runs.
Dan Uggla hit his second homer of the season, finishing 3-for-6 with two runs batted in, while Miguel Cabrera went 3-for-4 with two runs scored in the victory. Miguel Olivo ended 2-for-5 with a pair of RBI and two runs scored while Reggie Abercrombie also drove in two runs.
Jason Vargas was handed an early 6-0 lead, but could not get through the fifth frame to pick up the victory. Josh Johnson (1-1) pitched three scoreless innings to earn his first major-league victory.
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