Safarova came from behind to beat Australian Samantha Stosur 5-7, 6-1, 6-4, and Santangelo defeated France's Stephanie Foretz 6-2, 6-2.
A Day-1 upset saw Puerto Rico's Kristina Brandi beat Swede Sofia Arvidsson 7-5, 6-2. Arvidsson won in Memphis in February.
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