Sidney Crosby had a goal and two assists; Sergei Gonchar scored twice; John LeClair had a goal and an assist; and Andy Hilbert added two assists for the Penguins (19-42-12), who stopped a two-game skid.
Garth Snow, who started in goal for New York, allowed four goals on 29 shots. The Islanders (33-35-5) have lost three in a row.
Neither team will make the playoffs and are playing out the string.
Celebrity Breakups and divorces of 2014 [PHOTOS]