His No. 39 Dodge crossed the finish line 1.343 seconds ahead of runner-up Clint Bowyer.
Newman set a track record by leading 193 laps and tied the consecutive win mark set in 1983 by Sam Ard.
Late-race tire problems for Martin Truex Jr. mean he will go to the next race with just a 26-point lead over Bowyer (4,063-4,037). That race will take place at the Kansas Speedway on Oct. 8.
In lap three, when Matt Kenseth was spun out, nine cars were eliminated: Kenseth, Jeff Burton, Mark Green, Donnie Neuenberger, Randy LaJoie, Michael Waltrip, Johnny Sauter, David Green and Kevin Hamlin. The race was red-flagged for the lengthy clean-up period.