Damon Hollins added three hits and scored two runs and Carl Crawford hit a two-run homer for Tampa Bay, which had 13 hits overall.
Winner Casey Fossum (5-8) allowed two runs and only three hits in 6 1/3 innings with one walk and six strikeouts.
Loser Erik Bedard dropped to 5-2. He allowed three runs and nine hits in six innings with one walk and six strikeouts.
Sammy Sosa and Sal Fasano each homered for the Orioles, who have lost five in a row and seven of eight. Sosa has 585 career home runs and is one shy of Washington Manager and former Oriole Frank Robinson on the all-time list.